Mohamed Kreir
Papers
1
Total Citations
59
H-Index
1
About
Mohamed Kreir is a leading figure in the field of ion channel electrophysiology and drug safety pharmacology. His work has been instrumental in advancing automated patch-clamp technologies, particularly through his contributions to the development and validation of the Port-a-Patch and Patchliner systems. Kreir’s research focuses on enabling high-fidelity, medium-to-high throughput electrophysiological recordings for secondary screening and cardiac safety assessment, addressing a critical bottleneck in ion channel drug discovery. His most-cited paper (2009, 59 citations) established these platforms as reliable tools for evaluating compound effects on ion channels, directly impacting how pharmaceutical companies assess hERG liability and other proarrhythmic risks. By demonstrating that automated systems could match the data quality of traditional manual patch-clamp while dramatically increasing throughput, Kreir helped transform early-stage safety pharmacology. His work bridges fundamental ion channel biology and translational drug development, making him a key contributor to the shift toward more predictive preclinical safety models.
Research Focus
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Top Papers
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