Maggie Wacker
Papers
1
Total Citations
52
H-Index
1
About
Maggie Wacker is a distinguished pharmaceutical scientist whose research centers on the physicochemical characterization of drug candidates, with a particular emphasis on aqueous solubility and its critical role in drug lead optimization. Her most cited work, "An Automated Screening Assay for Determination of Aqueous Equilibrium Solubility Enabling SPR Study During Drug Lead Optimization" (2005, 52 citations), introduced a groundbreaking automated method for measuring equilibrium solubility. This assay directly addressed a major bottleneck in drug discovery by enabling robust structure-property relationship (SPR) studies, allowing researchers to systematically link molecular structure with solubility behavior. Wacker’s contribution is notable for its practical impact: it provided the high-throughput, sensitive analytical capacity needed to guide medicinal chemistry decisions during lead optimization, ultimately accelerating the selection of viable drug candidates. By bridging the gap between fundamental solubility science and applied drug development, her work has become a foundational reference for scientists seeking to integrate physicochemical property screening into early-stage discovery pipelines.
Research Focus
Key Achievements
Top Papers
- 1