Kenneth R. Williams
Papers
2
Total Citations
49
H-Index
2
About
Kenneth R. Williams has established himself as a significant contributor to the field of proteomics and mass spectrometry-based protein analysis. His research has focused primarily on the enzymatic digestion of proteins as a foundational technique for protein identification and structural analysis, work that has become increasingly vital in the post-genomic era. Williams' most recognized contributions center on developing and refining methodologies for enzymatic protein digestion, both in solution and within SDS polyacrylamide gels. His 2009 work on enzymatic digestion in solution and SDS gels, garnering 32 citations, highlights how the completion of numerous genome sequences combined with advances in mass spectrometry has revolutionized protein identification — enabling researchers to detect proteins at remarkably low femtomole and even subfemtomole levels, far surpassing the sensitivity of classical Edman chemical sequencing. His complementary 2004 paper, with 17 citations, elaborated on integrating gel-based digestion with mass spectrometric detection, further cementing these techniques as standard laboratory practice. Together, these contributions have provided researchers with practical, reliable protocols that underpin modern proteomic workflows. Students and researchers working in protein biochemistry, structural biology, and systems biology will find Williams' methodological work foundational to understanding how complex biological mixtures are analyzed at the molecular level today.
Research Focus
Key Achievements
Top Papers
- 1Enzymatic Digestion of Proteins in Solution and in SDS Polyacrylamide Gels32 citations · 2009
- 2