Helming Tan
Papers
1
Total Citations
52
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1
About
Helming Tan has made foundational contributions to the field of drug lead optimization, with a particular focus on the critical physicochemical property of aqueous solubility. Their most cited work, "An Automated Screening Assay for Determination of Aqueous Equilibrium Solubility Enabling SPR Study During Drug Lead Optimization" (2005, 52 citations), introduced a high-throughput, automated method for measuring equilibrium solubility—a parameter essential for structure-property relationship (SPR) studies. This assay addressed a major bottleneck in early drug discovery by providing reliable, sensitive solubility data that directly informed lead optimization decisions. Tan’s approach enabled researchers to systematically correlate molecular structure with solubility, thereby accelerating the identification of drug candidates with favorable pharmacokinetic profiles. The work’s enduring citation record reflects its practical impact on medicinal chemistry and pharmaceutical development. By bridging the gap between analytical sensitivity and throughput, Tan’s method has become a standard reference for scientists seeking to integrate solubility screening into their drug discovery pipelines. Their contributions exemplify how targeted methodological innovation can streamline the complex process of transforming chemical leads into viable therapeutics.
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