Chad R. Borges
Papers
2
Total Citations
92
H-Index
2
About
Chad R. Borges is a leading figure in clinical mass spectrometry, with his research centered on the development of high-throughput, quantitative assays for critical protein biomarkers. His major contributions lie in advancing mass spectrometric immunoassays (MSIA) for clinical diagnostics, particularly for managing growth hormone disorders. His seminal 2014 work on a parallel workflow for high-throughput analysis of human insulin-like growth factor 1 (IGF1) demonstrated the feasibility of processing over 1,000 samples per day, a pivotal step toward the widespread clinical adoption of MS-based IGF1 assays (52 citations). Borges has also made significant strides in bone biology, using mass spectrometry to precisely define the circulating proteoforms of osteocalcin, a key marker of bone turnover. His 2015 study revealed the specific gamma-carboxylation and fragmentation patterns of osteocalcin in human serum, providing essential molecular clarity for a biomarker previously defined only by immunological methods (40 citations). By bridging the gap between analytical chemistry and clinical application, Borges’s work is instrumental in translating powerful mass spectrometric techniques into routine, high-throughput clinical laboratory practice.
Research Focus
Key Achievements
Top Papers
- 1
- 2