Caroline L. Wiegerinck
Papers
1
Total Citations
174
H-Index
1
About
Caroline L. Wiegerinck is a leading researcher in epithelial cell biology and intestinal disorders, best known for her groundbreaking work on microvillus inclusion disease (MVID). Her most cited study, "Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease" (2014, 174 citations), fundamentally reshaped the understanding of this severe congenital diarrheal disorder. By identifying syntaxin 3 as a key player in apical membrane trafficking, Wiegerinck revealed a novel mechanism underlying variant MVID, distinguishing it from classic forms linked to myosin Vb. This discovery not only provided a molecular diagnosis for previously unexplained cases but also highlighted the critical role of SNARE proteins in intestinal epithelial polarity. Her work has had a profound impact on both clinical genetics and cell biology, offering new avenues for therapeutic intervention. With over 170 citations on this seminal paper alone, Wiegerinck’s contributions continue to guide research into enterocyte dysfunction and rare intestinal diseases, making her a pivotal figure in the field.
Research Focus
Key Achievements
Top Papers
- 1Loss of Syntaxin 3 Causes Variant Microvillus Inclusion Disease174 citations · 2014