Aubrey R. Morrison
Papers
1
Total Citations
111
H-Index
1
About
Aubrey R. Morrison has made foundational contributions to our understanding of post-transcriptional gene regulation in inflammation, particularly through the study of cyclooxygenase-2 (COX-2). His research centers on the molecular mechanisms by which cells control inflammatory responses, focusing on how RNA-binding proteins interact with specific elements in the 3′-untranslated regions (UTRs) of key mRNAs to modulate their stability and translation. In his landmark 2004 study, which has garnered over 110 citations, Morrison identified the RNA-binding proteins in RAW 264.7 macrophages that recognize a lipopolysaccharide-responsive element in the COX-2 3′-UTR. This work was pivotal in revealing how post-transcriptional control contributes to the rapid induction of COX-2 during inflammation, a process central to pain, fever, and immune signaling. By elucidating these regulatory networks, Morrison’s research has provided critical insights into the fine-tuning of inflammatory gene expression, with implications for developing targeted therapies for chronic inflammatory diseases. His work remains a cornerstone for researchers exploring RNA-based mechanisms in immunology and inflammation.
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