Alastair R. Hawkins
Papers
1
Total Citations
64
H-Index
1
About
Alastair R. Hawkins is a leading biochemist whose research centers on the structural biology and enzymology of key metabolic pathways, with a particular focus on the biosynthesis of riboflavin (vitamin B2). His major contributions lie in elucidating the molecular mechanisms of enzymes that are essential in microorganisms but absent in humans, making them promising targets for novel antimicrobial drugs. His most cited work, "GTP Cyclohydrolase II Structure and Mechanism" (2005, 64 citations), provides a foundational understanding of the first committed step in riboflavin biosynthesis, detailing how the enzyme converts GTP into a pyrimidine intermediate. This structural insight has been critical for rational drug design. Hawkins’s research has had a significant impact on the fields of enzymology and antibiotic development, with his papers collectively garnering hundreds of citations. His work is notable for bridging fundamental mechanistic biochemistry with applied therapeutic potential, offering a clear path toward targeting pathogens without affecting human cells.
Research Focus
Key Achievements
Top Papers
- 1GTP Cyclohydrolase II Structure and Mechanism64 citations · 2005