A. Isenegger

About

A. Isenegger is a leading figure in synchrotron instrumentation and automation, whose work has dramatically accelerated the pace of structural biology and materials science. At the Swiss Light Source (SLS), Isenegger was instrumental in developing the SLS Crystallization Platform at Beamline X06DA, a fully automated pipeline for *in situ* X-ray diffraction screening. This system, detailed in a highly influential 2011 paper (94 citations), revolutionized macromolecular crystallography by enabling high-throughput, hands-off sample analysis for both academic and industrial users. Complementing this, Isenegger pioneered high-throughput, full-automatic synchrotron-based tomographic microscopy at the TOMCAT beamline. By engineering a system capable of acquiring full tomographic datasets in just 5 to 10 minutes, with voxel sizes down to 0.37 µm, this work (37 citations) unlocked the potential for rapid, three-dimensional imaging of complex samples. Isenegger’s core contributions lie in transforming synchrotron beamlines from manual, time-intensive facilities into efficient, automated workhorses, profoundly impacting the throughput and accessibility of cutting-edge X-ray science.

Research Focus

Key Achievements

Top Papers

1. 1
   SLS Crystallization Platform at Beamline X06DA—A Fully Automated Pipeline Enabling <i>in Situ</i> X-ray Diffraction Screening

   94 citations · 2011
2. 2
   High-throughput full-automatic synchrotron-based tomographic microscopy

   37 citations · 2011

Key Collaborators

Contact & Links