Successful robotic-assisted liver resection after Yttrium-90 radioembolization in combination with targeted and immunotherapy in unresectable hepatocellular carcinoma:A case report and literature review

Abstract

To explore the clinical data and review the literature on successful robotic-assisted hepatectomy after yttrium-90 microsphere radioembolization (Y 90 -RE) combined with targeted therapy and immunotherapy for advanced unresectable hepatocellular carcinoma (HCC). We retrospectively analyzed a case of with advanced HCC patient in our center who successfully underwent robotic-assisted hepatectomy after Y 90 -RE combined with targeted therapy and immunotherapy. Additionally, we reviewed the related treatments and summarized the latest advances in domestic and international literature. The patient was a 65-year-old man, who underwent successful robotic-assisted hepatectomy after Y 90 -RE combined with targeted immunotherapy and was confirmed to achieve pathologically complete remission (pCR). Postoperative pathology showed that the tumor was necrotic, and no tumor residue was observed. The patient was followed up for more than six months, and no tumor recurrence was observed. In this case, Y 90 -RE combined with targeted immunotherapy as a preoperative conversion therapy ​option for advanced unresectable HCC was proven to be safe and feasible in this case.