Innovative strategies in the formulation and applications of mouth dissolving films for enhanced oral drug delivery

Abstract

OBJECTIVE: The main objective is to provide an overview of the advantages of mouth dissolving films (MDFs) by addressing the limitations of traditional oral dosage forms such as tablets and capsules, particularly for pediatric and geriatric patients with dysphagia. Also to explore its potential to revolutionize the oral drug delivery system supported by advancements in technology. SIGNIFICANCE: Mouth dissolving films offer a transformative approach for the delivery of drugs with rapid disintegration, ease of administration, and water-free administration that improve patient compliance significantly. This review highlights the MDFs formulation strategies, applications, patent portfolio, and role of emerging technologies like 3D printing and artificial intelligence in enhancing drug absorption and bioavailability with substantial commercial potential and versatility, offering a patient-centric solution to modern pharmaceutical challenges. KEY FINDINGS: Mouth dissolving film helps in addressing potential limitations in the traditional drug delivery system by enhancing patient compliance. This formulation relies on hydrophilic polymers and excipients to achieve desired characteristics, with techniques like solvent casting and 3D printing playing a pivotal role in their development, ensuring critical quality parameters that are essential for maintaining the efficacy and safety of the film with significant market potential. These dosage forms can offer good absorption and bioavailability by the use of artificial intelligence and microfabrication. CONCLUSION: Mouth dissolving films are a transformative progress in oral drug delivery with future advancements in AI, robotics, and microfabrication that hold promise to further enhance bioavailability, targeted delivery, and sustained release solidifying their role in modern pharmaceutics.