3D bioprinting directly onto moving human anatomy

Abstract

This paper establishes the feasibility of robotically 3D printing biomaterials such as alginate hydrogels onto moving human anatomy and a stationary plane. The alginate hydrogels used are in-vivo compatible and a proven biomaterial for tissue scaffolds. We developed a control scheme for precision material deposition via piezo microjetting while tracking in real-time to continuously sense anatomy location and deposits material in a predefined trajectory derived from two pre-selected target geometries. We show that multilayer 3D structures can be created on a moving human hand with 1.6 mm average error and 87.8 % overall accuracy.