Application of Automation and Thermal Analysis to Resolving Agent Selection

Abstract

The use of differential scanning calorimetry as a means to identify diastereoisomeric salts with a clear eutectic composition that is needed for effective resolution is described and forms the basis of a resolving agent screening process. Automated salt synthesis using an Advanced ChemTech robot is also described. Rapid data analysis is facilitated using an in-house software package, Resolution Companion, which also enables identification of the optimum crystallization conditions following a trial crystallization experiment.