Logic-Gated Plasmonic Nanodevices Based on DNA-Templated Assembly

Abstract

Open AccessCCS ChemistryCOMMUNICATION1 Mar 2021Logic-Gated Plasmonic Nanodevices Based on DNA-Templated Assembly Fengsong Liu†, Qiao Jiang†, Qing Liu, Na Li, Zihong Han, Chao Liu, Zhaoran Wang, Yunfei Jiao, Jiashu Sun and Baoquan Ding Fengsong Liu† CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 , Qiao Jiang† CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 , Qing Liu CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 , Na Li CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 , Zihong Han CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 , Chao Liu CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 , Zhaoran Wang CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 , Yunfei Jiao CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 , Jiashu Sun CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 and Baoquan Ding *Corresponding author: E-mail Address: [email protected] CAS Key Laboratory of Nanosystem and Hierarchical Fabrication, CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology, Beijing 100190 University of Chinese Academy of Sciences, Beijing 100049 School of Materials Science and Engineering, Zhengzhou University, Zhengzhou 450001 https://doi.org/10.31635/ccschem.020.202000300 SectionsSupplemental MaterialAboutAbstractPDF ToolsAdd to favoritesTrack Citations ShareFacebookTwitterLinked InEmail Life has evolved numerous elegant molecular machines that recognize biological signals and affect mechanical changes precisely to achieve specific and versatile biofunctions. Inspired by nature, synthetic molecular machines could be designed rationally to realize nanomechanical operations and autonomous computing. We constructed logic-gated plasmonic nanodevices through coassembly of two gold nanorods (AuNRs) and computing elements on a tweezer-shaped DNA origami template. After recognition of various molecular inputs, such as DNA strands, glutathione, or adenosine, the geometry and plasmonic circular dichroism (CD) signals of the AuNR–origami nanodevices produced corresponding changes. Then we designed and characterized a set of modular Boolean logic-gated nanodevices (YES, NOT, AND, OR) and proceeded to construct a complicated 3-input circuit capable of performing Boolean OR-NOT-AND operations. Our plasmonic logic devices transduced external inputs into conformational changes and near-infrared (NIR) chiral outputs. This DNA-based self-assembly strategy holds great potential for applications in programmable optical modulators, molecular information processing, and bioanalysis. Download figure Download PowerPoint Introduction Nature has evolved numerous molecular machines that res