Automated Genomic Interpretation via Concept Bottleneck Models for Medical Robotics

Abstract

We propose an automated genomic interpretation module that transforms raw DNA sequences into actionable, interpretable decisions suitable for integration into medical automation and robotic systems. Our framework combines Chaos Game Representation (CGR) with a Concept Bottleneck Model (CBM), enforcing predictions to flow through biologically meaningful concepts such as GC content, CpG density, and k mer motifs. To enhance reliability, we incorporate concept fidelity supervision, prior consistency alignment, KL distribution matching, and uncertainty calibration. Beyond accurate classification of HIV subtypes across both in-house and LANL datasets, our module delivers interpretable evidence that can be directly validated against biological priors. A cost aware recommendation layer further translates predictive outputs into decision policies that balance accuracy, calibration, and clinical utility, reducing unnecessary retests and improving efficiency. Extensive experiments demonstrate that the proposed system achieves state of the art classification performance, superior concept prediction fidelity, and more favorable cost benefit trade-offs compared to existing baselines. By bridging the gap between interpretable genomic modeling and automated decision-making, this work establishes a reliable foundation for robotic and clinical automation in genomic medicine.