Vincent J. Higgins
Papers
2
Total Citations
80
H-Index
2
About
Vincent J. Higgins is a molecular biologist whose research centers on yeast functional genomics and the cellular response to oxidative stress. His most significant contribution lies in pioneering high-throughput phenotypic screening of yeast gene deletion mutants to systematically identify genes involved in oxidative stress sensitivity. In his landmark 2001 study (78 citations), Higgins employed microtitre plates and robotics to screen over 600 deletion strains from the EUROSCARF collection, providing a powerful platform for elucidating gene function through growth phenotype analysis under oxidative challenge. This work established a foundational methodology for connecting genotype to phenotype on a genomic scale, enabling researchers to pinpoint genes critical for cellular defense against reactive oxygen species. Higgins’ approach has been widely adopted in functional genomics, demonstrating the utility of yeast as a model for understanding stress response pathways relevant to aging, disease, and biotechnology. His research continues to inform how cells maintain redox homeostasis, with implications for therapeutic target identification.
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Top Papers
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