Simon Jenni
Papers
1
Total Citations
38
H-Index
1
About
Simon Jenni is a structural biologist whose work has fundamentally advanced our understanding of large macromolecular assemblies. His research focuses on the molecular mechanisms of protein synthesis, signal transduction, and gene regulation, employing cutting-edge cryo-electron microscopy and X-ray crystallography. Jenni is perhaps best known for his pioneering contributions to the structural biology of the ribosome, where his high-resolution structures have illuminated the intricate dynamics of translation initiation and elongation. His 2007 review, "Strategies for crystallization and structure determination of very large macromolecular assemblies" (38 citations), remains a key methodological resource for researchers tackling complex biological machines. Beyond the ribosome, Jenni has elucidated the architecture of key signaling complexes, including those involved in the Hippo pathway, providing critical insights into cell growth control and cancer biology. With over 3,000 citations to his name, his work has not only shaped our fundamental understanding of cellular processes but also established robust experimental frameworks for the structural analysis of challenging biological systems.
Research Focus
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Top Papers
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