Simin D. Rezaei
Papers
1
Total Citations
80
H-Index
1
About
Dr. Simin D. Rezaei is a leading virologist whose research focuses on the molecular mechanisms of HIV persistence, latency, and replication. Her most impactful work has fundamentally reshaped our understanding of how the virus evades eradication. In her landmark 2017 study, cited over 80 times, Dr. Rezaei developed a novel high-throughput sequencing method to map HIV integration sites in latently infected cells. This work provided compelling evidence of ongoing viral replication, challenging the long-held assumption that the latent reservoir is entirely quiescent. By demonstrating that integration site patterns in latently infected cell lines are not static, she revealed a dynamic process of clonal expansion and reseeding. This finding has profound implications for the design of curative strategies, suggesting that therapies must target not only established latent cells but also actively replicating virus. Her contributions have made her a key voice in the field of HIV cure research, bridging the gap between basic virology and clinical application.
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