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About

Shuzhen Sim is a leading researcher in the field of vector-borne disease control, with a primary focus on the use of *Wolbachia*-mediated sterility to combat dengue. Her work centers on evaluating the real-world efficacy of releasing male *Aedes aegypti* mosquitoes infected with the wAlbB strain of *Wolbachia*, which mate with wild females to produce non-viable eggs. Sim’s major contributions include landmark synthetic control studies in Singapore, demonstrating that this incompatible insect technique (IIT), often coupled with the sterile insect technique (SIT), can significantly suppress mosquito populations and reduce dengue incidence. Her 2024 paper on the efficacy of *Wolbachia*-mediated sterility has garnered 80 citations, while a companion study on IIT-SIT suppression has received 46 citations, underscoring their high impact. By emulating cluster randomized target trials, Sim provides rigorous, actionable evidence for public health policy. Her work is pivotal in advancing non-chemical, sustainable strategies for dengue control, offering hope for regions burdened by this mosquito-borne disease.