Scott R. Budihas
Papers
1
Total Citations
128
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1
About
Scott R. Budihas is a biochemist and assay development specialist whose work has significantly advanced antiviral drug discovery, particularly against HIV-1. His primary research focus lies in the design and implementation of high-throughput screening (HTS) assays to identify inhibitors of critical viral enzymes. Budihas is best known for developing a groundbreaking fluorescence-based HTS assay targeting the ribonuclease H (RNase H) activity of HIV-1 reverse transcriptase, a notoriously difficult drug target. This seminal 2003 work, which has garnered over 128 citations, provided the field with a robust, scalable tool to probe for novel inhibitors, overcoming prior limitations in assay sensitivity and throughput. By enabling the rapid screening of large compound libraries, his contribution directly facilitated the discovery of new lead molecules against HIV. Budihas’s expertise in assay miniaturization and fluorescence technologies has made him a key figure in bridging the gap between basic enzymology and practical drug development, with his methodologies influencing subsequent studies on other viral and bacterial RNases.
Research Focus
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