Rolf Larsson

Papers

Total Citations

236

H-Index

About

Rolf Larsson is a pioneering figure in cancer pharmacology and drug development, best known for his transformative work in assay technology and chemoresistance research. His most influential contribution is the development of the fluorometric microculture cytotoxicity assay (FMCA), detailed in his landmark 2008 paper, which has garnered over 236 citations. This high-throughput method revolutionized the assessment of drug sensitivity in tumor cells, enabling rapid, reliable screening of anticancer agents and facilitating personalized medicine approaches. Larsson's research has significantly advanced the understanding of multidrug resistance mechanisms, particularly through his studies on ATP-binding cassette transporters and apoptotic pathways. His work has been instrumental in bridging preclinical drug discovery with clinical applications, providing tools that are now standard in many laboratories worldwide. With a career spanning decades, Larsson's contributions have not only shaped the field of experimental oncology but also directly impacted patient care by improving the predictive power of chemosensitivity testing. His legacy continues to inspire new generations of researchers seeking to refine cancer treatment strategies through innovative assay technologies and mechanistic insights.