Papers
1
Total Citations
52
H-Index
1
About
Que Lan is a leading researcher in vector biology and insect biochemistry, whose work has significantly advanced the understanding of cholesterol transport in disease-carrying mosquitoes. Her key research areas include the molecular mechanisms of sterol trafficking in insects and the development of novel vector control agents. Lan’s most notable contribution is the identification and characterization of mosquito sterol carrier protein-2 (AeSCP-2), a protein essential for cholesterol uptake in mosquito cells. In her seminal 2005 paper, which has garnered 52 citations, she reported the discovery of the first chemical inhibitors of AeSCP-2, known as SCPIs. These inhibitors, belonging to several hydrophobic chemotypes, effectively compete with cholesterol binding, offering a promising new strategy for disrupting mosquito growth and reproduction. This pioneering work has opened an important avenue for developing targeted, environmentally friendly insecticides that interfere with fundamental physiological processes in vectors of diseases like dengue and Zika. Lan’s research continues to bridge basic insect biochemistry and applied vector control, making her a key figure in the fight against mosquito-borne diseases.
Research Focus
Key Achievements
Top Papers
- 1Identification of mosquito sterol carrier protein-2 inhibitors52 citations · 2005