Paolo Plevani

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About

Paolo Plevani is a leading molecular biologist whose work has fundamentally advanced our understanding of DNA replication, cell cycle control, and the DNA damage response in eukaryotic cells. His research has been instrumental in elucidating how cells maintain genomic stability, particularly through the study of the S-phase checkpoint and the role of key protein kinases. Plevani’s major contributions include the discovery and functional characterization of the yeast Cdc7 kinase and its regulatory subunit Dbf4, which are essential for the initiation of DNA replication. His work has also shed light on the mechanisms by which cells coordinate DNA replication with repair processes, providing a molecular framework for understanding how genomic integrity is preserved. With over 7,000 citations, his findings have had a profound impact on cancer biology, as defects in these pathways are linked to tumorigenesis. Notably, his highly cited 2006 paper in *BioTechniques* introduced a one-step high-throughput assay for β-galactosidase activity, a versatile tool now widely used in bacterial, yeast, and mammalian systems. Plevani’s research continues to inspire new generations of scientists exploring the intricate dance of DNA metabolism and cell cycle regulation.