Noam Shoresh

Papers

Total Citations

126

H-Index

About

Noam Shoresh is a leading researcher in the field of bacterial antibiotic tolerance and persistence, areas critical to understanding treatment failure and relapse in infectious disease. His major contribution lies in developing rigorous experimental frameworks to quantify these phenomena, which are distinct from antibiotic resistance. While resistance is measured by the minimum inhibitory concentration (MIC), tolerance and persistence lack standardized clinical metrics. Shoresh’s foundational 2017 paper, “An Experimental Framework for Quantifying Bacterial Tolerance,” has garnered 126 citations, establishing a methodology that distinguishes between the ability of bacteria to survive transient antibiotic exposure (tolerance) and the presence of subpopulations that persist (persistence). This work provides a quantitative basis for studying these poorly characterized mechanisms, offering potential for improved diagnostic and therapeutic strategies. Shoresh’s research bridges a critical gap in microbiology and clinical practice, making his contributions highly influential for students and researchers seeking to understand and combat bacterial survival strategies beyond traditional resistance.