Meriem Semache
Papers
1
Total Citations
152
H-Index
1
About
Meriem Semache is a prominent researcher in lipid metabolism and adipose biology, best known for her groundbreaking work on the molecular mechanisms of lipolysis. Her key research areas include the enzymatic regulation of triglyceride hydrolysis, energy homeostasis in white adipose tissue, and the identification of alternative lipolytic pathways. Her most-cited study, "Carboxylesterase 3 (EC 3.1.1.1) Is a Major Adipocyte Lipase" (2004, 152 citations), fundamentally challenged the prevailing view that hormone-sensitive lipase (HSL) was the sole mediator of lipolysis. By demonstrating that HSL-deficient mice retain significant lipolytic activity, Semache’s work revealed carboxylesterase 3 as a major adipocyte lipase, reshaping our understanding of fat mobilization and energy balance. This discovery has had lasting impact on metabolic research, influencing studies on obesity, insulin resistance, and lipid disorders. Her contributions underscore the complexity of adipose tissue regulation and have opened new avenues for therapeutic targeting. Semache’s research continues to inspire investigations into the redundant and compensatory mechanisms that govern lipid metabolism, making her a key figure in the field.
Research Focus
Key Achievements
Top Papers
- 1Carboxylesterase 3 (EC 3.1.1.1) Is a Major Adipocyte Lipase152 citations · 2004