Masato Enari
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1
Total Citations
326
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1
About
Masato Enari is a leading figure in prion biology, whose work has fundamentally advanced the quantitative study of prion diseases. His key research areas center on the molecular mechanisms of prion propagation and the development of innovative, high-throughput assays to replace slow and costly animal bioassays. Enari’s most impactful contribution is the creation of a highly sensitive cell-based infectivity assay for mouse scrapie prions, published in 2003 and cited over 326 times. By isolating neuroblastoma N2a sublines that are uniquely susceptible to prion infection, his team enabled the rapid, precise quantification of infectivity and the scrapie form of prion protein (PrPSc). This breakthrough transformed prion research, providing a reliable in vitro platform that dramatically reduced reliance on animal models. Enari’s work has been instrumental in elucidating the cellular factors governing prion susceptibility and has opened new avenues for screening anti-prion compounds. His achievements stand as a cornerstone in the field, offering both a powerful tool for basic science and a practical step toward therapeutic development.
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