Martina Tholen

Papers

Total Citations

139

H-Index

About

Martina Tholen is a leading figure in the field of molecular imaging and surgical oncology, whose work is redefining the boundaries of fluorescence-guided surgery. Her primary research focuses on the development of smart, activatable contrast agents that can illuminate diseased tissue with unprecedented precision. Tholen's most significant contribution is the creation of "AND-gate" contrast agents, a groundbreaking concept that requires two distinct biological triggers to activate, dramatically reducing background signal and false positives. Her seminal 2020 paper on this topic has garnered 139 citations, underscoring its impact on the field. This innovation promises to enhance the surgeon's ability to distinguish malignant from healthy tissue in real time, potentially improving patient outcomes in cancer resections. Beyond this, Tholen's work integrates principles of chemistry, biology, and biomedical engineering, positioning her as a key architect of next-generation intraoperative imaging. Her achievements have not only advanced fundamental knowledge but also paved the way for clinical translation, making her a vital voice in the future of precision surgery.