Marcello De Angelis

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About

Dr. Marcello De Angelis is a leading clinical researcher at the intersection of neurology and digital health, with a primary focus on multiple sclerosis (MS). His major contributions center on systematically evaluating how digital technologies—including wearable sensors, mobile apps, and remote monitoring tools—can transform clinical trial design and patient care in MS. His landmark 2021 systematic review, which has garnered 40 citations, provided the first comprehensive map of digital tool integration in MS trials, identifying critical gaps in standardization and validation. This work has become a foundational reference for researchers seeking to modernize trial endpoints and improve real-world disease tracking. Beyond this, Dr. De Angelis has been instrumental in advancing patient-centric outcomes, demonstrating how digital biomarkers can capture disability progression and treatment response with greater sensitivity than traditional clinic-based assessments. His research bridges the gap between rigorous clinical methodology and cutting-edge technology, offering practical frameworks for implementing digital endpoints in regulatory-grade studies. For students and researchers, his work represents a vital roadmap for the future of decentralized, data-rich clinical trials in neurology.