Luis M. Cacharro
Papers
1
Total Citations
89
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1
About
Luis M. Cacharro is a leading researcher in lipid biology and cancer pharmacology, whose work has fundamentally advanced our understanding of how membrane composition influences drug action. His research focuses on the interplay between lipid rafts, sterol metabolism, and sphingolipid pathways in cellular stress responses and antitumor therapy. Cacharro’s most notable contribution is his pioneering study on the cytotoxicity of edelfosine, an anti-cancer lysophospholipid, in which he used *Saccharomyces cerevisiae* as a model system to identify sterol and sphingolipid pathways as key regulators of drug sensitivity. This work, published in 2005 and cited 89 times, demonstrated that edelfosine selectively modifies lipid raft composition, revealing a novel mechanism of action for alkylphosphocholine drugs. By linking membrane lipid architecture to drug efficacy, Cacharro’s findings have opened new avenues for targeted cancer therapy and provided a foundation for understanding how lipid microdomains govern cellular responses to chemotherapeutic agents. His research continues to inspire investigations into lipid-mediated drug resistance and the development of more selective anticancer compounds.
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