Ludovic Pecqueur
Commissariat à l'Énergie Atomique et aux Énergies Alternatives
Papers
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Total Citations
112
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About
Ludovic Pecqueur is a structural biologist whose research centers on the molecular mechanisms of metal-dependent regulation in bacteria, with a particular focus on the ferric uptake regulator (Fur) protein. His major contribution lies in elucidating the structural dynamics of *Escherichia coli* Fur, demonstrating how metal binding induces conformational changes that drive dimerization and DNA-binding activation. Using a powerful combination of NMR and X-ray crystallography, Pecqueur’s seminal 2006 paper (112 citations) provided the first detailed view of Fur’s structural transitions, revealing how iron acts as a molecular switch to control gene expression. This work has had lasting impact, informing studies on bacterial iron homeostasis and virulence regulation. Beyond this, Pecqueur’s research continues to explore how metalloproteins sense and respond to environmental cues, bridging structural biology and microbiology. His findings are essential for understanding bacterial adaptation and for developing novel antimicrobial strategies targeting metal-dependent regulatory pathways.
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Top Papers
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