Joelle M. Onorato
Papers
2
Total Citations
45
H-Index
2
About
Joelle M. Onorato is a distinguished bioanalytical chemist whose career has advanced the frontiers of drug discovery and metabolic disease research. Her work is anchored in the development of high-throughput, robust liquid chromatography-tandem mass spectrometry (LC-MS/MS) methods, a key area where she has made transformative contributions. In a seminal 2000 paper (34 citations), she pioneered a robotic, sequential sample injection technique for the rapid quantification of idoxifene and its metabolite in human plasma, directly addressing the critical need for speed and selectivity in early-stage pharmaceutical analysis. This work established a benchmark for high-throughput bioanalysis. Onorato further demonstrated her versatility by developing a novel cell-based assay for monoacylglycerol acyltransferase 2 (MGAT2) activity, a therapeutic target for metabolic disorders. By employing a stable isotope-labeled substrate and high-resolution LC/MS, she circumvented the limitations of traditional radiolabeled methods, providing a more precise and scalable platform for inhibitor profiling. Her contributions have not only yielded practical, high-impact analytical tools but have also deepened our understanding of lipid metabolism, making her a respected figure in both analytical chemistry and drug development.
Research Focus
Key Achievements
Top Papers
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