Papers
1
Total Citations
31
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About
Jean Mathieu is a leading clinical researcher in neuromuscular and neurodegenerative disorders, with a particular focus on autosomal recessive spastic ataxia of Charlevoix-Saguenay (ARSACS). His pioneering work has advanced the understanding and assessment of upper limb coordination deficits in ARSACS patients, most notably through the development and validation of the Virtual Peg Insertion Test. This innovative tool, detailed in his highly cited 2014 pilot study (31 citations), offers a sensitive, quantitative measure of motor dysfunction, enabling more precise tracking of disease progression and therapeutic outcomes. Mathieu’s contributions have bridged the gap between clinical neurology and rehabilitation technology, providing clinicians with objective metrics to evaluate fine motor control in rare ataxias. His research has been instrumental in characterizing the natural history of ARSACS, informing both patient care and clinical trial design. Through his methodical approach to motor assessment, Mathieu has established a framework for translating complex neurological deficits into actionable clinical data, making him a key figure in the study of hereditary ataxias and their management.
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