Erin Hugger
Papers
1
Total Citations
28
H-Index
1
About
Erin Hugger is a researcher whose work has significantly advanced the understanding of drug transport and metabolism, particularly through the lens of P-glycoprotein (P-gp) inhibition. Her most cited study, "Automated Analysis of Polyethylene Glycol-Induced Inhibition of P-Glycoprotein Activity In Vitro" (2002, 28 citations), stands as a foundational contribution to the field. In this work, Hugger pioneered an automated, high-throughput method to evaluate how common pharmaceutical excipients, such as polyethylene glycol, can modulate P-gp activity. This research was critical in revealing that seemingly inert formulation components can directly influence drug efflux, thereby affecting oral bioavailability and therapeutic efficacy. By providing a robust in vitro assay, Hugger’s findings have informed the rational design of drug delivery systems, helping researchers avoid unintended interactions that could compromise drug absorption. Her contributions underscore the importance of excipient selection in pharmaceutical development, and her work continues to be cited by those investigating transporter-mediated drug disposition. Hugger’s research exemplifies how meticulous in vitro analysis can bridge the gap between basic transport biology and practical drug formulation.
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Top Papers
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