David M. Perrin
Papers
1
Total Citations
42
H-Index
1
About
David M. Perrin is a leading figure in radiochemistry and molecular imaging, renowned for pioneering the development of novel ¹⁸F-labeling methodologies for positron emission tomography (PET) tracers. His major contributions center on overcoming the long-standing challenge of incorporating aqueous fluoride-18 into biomolecules under mild, biocompatible conditions. Perrin’s seminal work introduced the use of aryltrifluoroborates for rapid, one-step isotope exchange, enabling high-yielding radiolabeling at very high specific activity—a breakthrough that has fundamentally advanced the field. This innovation, detailed in his highly cited 2012 paper (42 citations), has provided a practical route for producing stable, aqueous-phase radiotracers without harsh organic solvents or elevated temperatures, thereby expanding the scope of PET imaging for biological research and clinical diagnostics. Beyond this, his research has significantly impacted the design of hydrolytically stable boron-based prosthetic groups for bioconjugation. Perrin’s work is widely recognized for its elegance and translational potential, earning him a reputation as a transformative thinker in radiopharmaceutical chemistry. His contributions continue to inspire new strategies for developing next-generation imaging agents.
Research Focus
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Top Papers
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