Darlene E. Graner
Papers
2
Total Citations
55
H-Index
2
About
Darlene E. Graner is a leading clinical researcher in head and neck oncology, with a focused expertise in de-escalation treatment strategies for human papillomavirus-positive oropharyngeal cancer. Her work centers on improving functional outcomes and quality of life for patients with highly curable HPV-positive disease, particularly through the integration of transoral robotic surgery (TORS) and tailored adjuvant therapy. Her landmark 2019 study, "Outcomes following TORS for HPV-positive oropharyngeal carcinoma," with 36 citations, provided critical evidence on the feasibility of TORS in reducing the need for gastrostomy tubes and tracheostomies, directly impacting postoperative recovery and swallowing function. Graner further advanced the field as a key investigator on the MC1273 phase 2 trial, published in 2022 (19 citations), which demonstrated that dose de-escalation of adjuvant chemoradiation after TORS can significantly lower long-term toxic effects while maintaining excellent oncologic control. Her contributions are shaping a paradigm shift toward less morbid, personalized treatment protocols, making her a pivotal figure in the movement to preserve quality of life for survivors of HPV-positive oropharyngeal cancer.
Research Focus
Key Achievements
Top Papers
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