Charles T. Campbell
Papers
3
Total Citations
262
H-Index
3
About
Charles T. Campbell has established himself as a pioneering figure in the development of surface plasmon resonance (SPR) microscopy for high-throughput biomolecular analysis. His research sits at the intersection of analytical chemistry, biophysics, and genomics, with a particular focus on quantitative, real-time characterization of protein-DNA and protein-biomolecule interactions at surfaces. Campbell's most influential contributions center on the innovative use of SPR microscopy to simultaneously monitor binding events across dense microarray formats. His landmark 2004 studies — each garnering over 128 citations — demonstrated that kinetic measurements of sequence-specific DNA-binding proteins could be performed across 120-element double-stranded DNA arrays on gold surfaces, a significant leap in throughput and precision over conventional methods. By developing robust microspotting strategies using streptavidin-biotin linkage chemistry, he enabled scalable, reproducible array fabrication that opened new avenues in transcription factor research and genomic screening. Building on this foundation, Campbell extended his platform to immunoassays and small molecule binding on protein microarrays, broadening the technique's utility across drug discovery and diagnostics. His work has provided researchers with powerful, label-free tools for dissecting complex biomolecular recognition events with remarkable sensitivity and spatial resolution.
Research Focus
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Top Papers
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