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About

Carleen Klumpp-Thomas is a researcher specializing in high-throughput screening (HTS) methodologies, with a particular focus on in vitro toxicology and drug combination discovery. Her work addresses one of the most pressing challenges in modern pharmacology: the need to efficiently evaluate the safety and efficacy of the growing number of chemical compounds entering research and development pipelines. Her most impactful contribution, "High-Throughput Screening to Advance In Vitro Toxicology" (2023), has garnered 49 citations and tackles the fundamental limitations of traditional animal-based toxicity testing — namely its low throughput, high cost, and frequent failure to accurately predict human toxicity. By championing scalable, human-relevant in vitro approaches, Klumpp-Thomas is helping reshape how the scientific community assesses chemical risk. Her earlier work on screening methodologies for drug combinations (2019, 20 citations) further demonstrates her commitment to accelerating therapeutic discovery through innovative experimental design. Collectively, her research is particularly valuable to students and scientists working at the intersection of pharmacology, toxicology, and drug development, offering practical frameworks for making preclinical research faster, more ethical, and more predictive of real-world human outcomes.