Alexandra Sontheimer-Phelps
Papers
3
Total Citations
872
H-Index
3
About
Dr. Alexandra Sontheimer-Phelps is a pioneering figure in the development of advanced organ-on-chip technologies, with a primary focus on creating integrated, multi-organ platforms that recapitulate human physiology for drug testing. Her major contributions center on the automation and fluidic coupling of vascularized organ chips, enabling unprecedented simulation of systemic human responses. Her landmark 2020 paper, "Quantitative prediction of human pharmacokinetic responses to drugs via fluidically coupled vascularized organ chips," has garnered 463 citations, demonstrating its profound impact on the field. That same year, her work on "Robotic fluidic coupling and interrogation of multiple vascularized organ chips" earned 401 citations, showcasing her role in advancing high-throughput, automated platforms. Dr. Sontheimer-Phelps also led the development of the ‘Interrogator’ instrument, a robotic system detailed in a 2019 study that automates culture, perfusion, and imaging of up to 10 Organ Chips simultaneously. This innovation, while still emerging with 8 citations, represents a critical step toward scalable, body-on-chips experimentation. Her research bridges engineering and biology, offering transformative tools for predicting human drug responses and reducing reliance on animal models.
Research Focus
Key Achievements
Top Papers
- 1
- 2Robotic fluidic coupling and interrogation of multiple vascularized organ chips401 citations · 2020
- 3