Alexa Hofer
Papers
2
Total Citations
10
H-Index
2
About
Alexa Hofer is an emerging analytical chemist and biomedical researcher whose work sits at the intersection of metabolomics, clinical diagnostics, and cancer biology. Her research focuses on the development and optimization of advanced mass spectrometry-based methods for quantifying amino acids and their metabolites in human biofluids, with particular emphasis on tryptophan metabolism and its relevance to disease pathology. Hofer's most notable contribution to date is her development of an automated liquid handling extraction workflow coupled with dual-column ultra-high-performance liquid chromatography and multiple reaction monitoring mass spectrometry (U(H)PLC-MRM-MS) for the rapid, underivatized quantification of amino acids and tryptophan metabolites from human serum and plasma. This technically sophisticated approach streamlines sample preparation, reduces analytical time, and enhances reproducibility — critically important qualities for translational clinical research. Her application of this methodology to prostate cancer studies highlights her commitment to linking biochemical measurement innovation with real-world diagnostic relevance. Having accumulated citations across both versions of her landmark 2024 publication, Hofer is establishing herself as a methodological innovator in clinical metabolomics. Her work is particularly valuable for researchers seeking robust, high-throughput biomarker discovery platforms in oncology and metabolic disease contexts.
Research Focus
Key Achievements
Top Papers
- 1
- 2
Key Collaborators
Related papers
- Automated Liquid Handling Extraction and Rapid Quantification of Underivatized Amino Acids and Tryptophan Metabolites from Human Serum and Plasma Using Dual-Column U(H)PLC-MRM-MS and Its Application to Prostate Cancer Study
- Automated liquid handling extraction and rapid quantification of underivatized amino acids and tryptophan metabolites from human serum and plasma using dual-column U(H)PLC-MRM-MS and its application to prostate cancer study
- Salting-out assisted liquid-liquid extraction for UPLC-MS/MS determination of bile acids and kynurenine-, indole- and serotonin-pathway metabolites of tryptophan in human serum of healthy probands
- Fully automated peptide mapping multi-attribute method by liquid chromatography–mass spectrometry with robotic liquid handling system
- Comprehensive and Scalable Highly Automated MS-Based Proteomic Workflow for Clinical Biomarker Discovery in Human Plasma
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