Paolo L. Manfredi
Papers
1
Total Citations
6
H-Index
1
About
Paolo L. Manfredi is a leading clinical researcher in psychopharmacology, with a focused expertise in treatment-resistant depression, dissociative disorders, and the therapeutic potential of novel glutamatergic agents. His major contributions center on the rapid-acting antidepressant effects of esmethadone (REL-1017), particularly its ability to alleviate dissociative symptoms in patients who have not responded to standard antidepressants. In his pivotal 2022 study, Manfredi demonstrated that REL-1017 may rapidly reduce dissociative states in adults with major depressive disorder, a finding with significant clinical implications given that dissociative disorders are highly prevalent—affecting up to 29% of psychiatric outpatients—yet remain severely underdiagnosed, with only 5% receiving a prior diagnosis. This work, cited 6 times, underscores his role in bridging a critical gap in psychiatric care. Manfredi’s research not only advances the understanding of NMDA receptor modulation but also offers new hope for patients with complex, refractory conditions. His ongoing investigations continue to shape the landscape of rapid-acting antidepressants and personalized psychiatric treatment.
Research Focus
Key Achievements
Top Papers
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