Mirja Osnabruegge

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About

Mirja Osnabruegge is a researcher advancing the precision and reliability of Transcranial Magnetic Stimulation (TMS) methodology, with a core focus on motor cortex stimulation and neuromodulation. Her most notable contribution is the development of the Semi-Automated Motor Hotspot Search (SAMHS) framework, a pioneering approach that optimizes motor hotspot identification—a critical first step for determining motor threshold and setting stimulation intensity in TMS applications. This work, published in 2023 and already garnering 10 citations, addresses a key source of variability in TMS research by reducing dependence on experimenter experience. Osnabruegge further investigates factors influencing rTMS aftereffects, as demonstrated in her 2025 study on how current direction affects 1 Hz motor cortex rTMS, contributing to the ongoing effort to improve replicability in neuromodulation. Her research is particularly impactful for students and researchers seeking to standardize TMS protocols, enhance experimental rigor, and understand the nuanced parameters that shape brain stimulation outcomes. Through these contributions, Osnabruegge is helping to build a more robust foundation for both clinical and research applications of TMS.