Mantle cell lymphoma of the colon: case report and literature review

Abstract

Primary extranodal lymphoma is a rare presentation of B-cell non-Hodgkin's lymphoma (NHL), most commonly found in the gastrointestinal tract. Mantle cell lymphoma (MCL), a rare and aggressive subtype, accounts for only 2.5% of all lymphoid neoplasms and is less commonly localized in the colon. We present a 79-year-old man with abdominal pain and nausea. Imaging revealed cecal wall thickening with ileocolic intussusception. Colonoscopy identified a circumferential cecal mass, necessitating robotic-assisted right hemicolectomy. Final pathology confirmed MCL. The patient recovered well without complications. Colorectal MCL is a rare and aggressive NHL variant requiring a multidisciplinary approach. Surgery plays a crucial role in managing complications and localized disease. Given the lack of standardized treatment protocols, further research is needed to optimize therapeutic strategies and long-term outcomes.