Instrumentation for Combinatorial Chemistry

Abstract

This chapter contains sections titled: Automation in Combinatorial Synthesis General Remarks Fully Automated Systems for Solid- and Solution-phase Synthesis Robot-arm-based Systems Fully Automated Workstation Systems Modular Systems Purification of Combinatorial Libraries Automated Liquid–Liquid Extraction Solid-phase Extraction Normal Phase Chromatography CombiFlash™ from Isco Quad3™ from Biotage FlashMaster™ from Jones Chromatography Reversed Phase Chromatography Biotage Gilson Merck Varian Shimadzu Preparative HPLC-MS PE Sciex Waters Micromass Merck-Hitachi Shimadzu Gilson ThermoQuest Analysis of Combinatorial Libraries Purity of Combinatorial Libraries Identity of Combinatorial Libraries Quantification of Combinatorial Libraries Automated Sample Processing Sample Logistics Evaporation References