Automated Column and Solvent Selection for Fully Automated HPLC Analyses of Tablet Content Uniformity

Abstract

An unat tended robot ic system that tests the content un i fo rmi ty of ant ihyper tensive tablet formula t ions is descr ibed. The system consis ts of a robot integrated w i th programmable h igh per formance l iquid chromatography (HPLC) equipment and a laboratory computer, and it a l lows the automat ion of sample preparat ion, HPLC analysis, and report generat ion. It also selects the HPLC co lumn and the mobi le phase t h r o u g h the use of program-contro l led c o l u m n and solvent se lectors. HPLC pump and detector parameters ( f low rate, wave length, and attenuat ion) are programmable and are selected by the robot ic s y s t e m.