ClC-3 and IClswell are Required for Normal Neutrophil Chemotaxis and Shape Change

Abstract

Polymorphonuclear leukocytes undergo directed movement to sites of infection, a complex process known as chemotaxis. Extension of the polymorphonuclear leukocyte (PMN) leading edge toward a chemoattractant in association with uropod retraction must involve a coordinated increase/decrease in membrane, redistribution of cell volume, or both. Deficits in PMN phagocytosis PMN the in cell PMN of cell the directed cell movement of with in to cell to undergo of to a of in or as a the to in PMN chemotaxis. in of PMN PMN of Polymorphonuclear leukocytes undergo directed movement to sites of infection, a complex process known as chemotaxis. Extension of the polymorphonuclear leukocyte (PMN) leading edge toward a chemoattractant in association with uropod retraction must involve a coordinated increase/decrease in membrane, redistribution of cell volume, or both. Deficits in PMN phagocytosis PMN the in cell PMN of cell the directed cell movement of with in to cell to undergo of to a of in or as a the to in PMN chemotaxis. in of PMN PMN of Polymorphonuclear leukocytes polymorphonuclear polymorphonuclear in the undergo directed movement to sites of or a process known as chemotaxis. chemoattractant of the the the of of the PMN leading edge of the retraction of the uropod directed movement toward a the movement to a of PMN cell with leading edge toward a uropod must involve a directed increase/decrease in a redistribution of volume, or both. known the of the in cell the a cell to the of cell in in a the leading edge a the edge retraction of the uropod in to a in process the of cell in PMN the process in to with the the as as a of the a process the cell a to the in the of the in the of the the to of the PMN of of with a a cell in of the the the of the in PMN in the of in PMN of a of with the of with or phagocytosis with in the of the in to a in in the in PMN phagocytosis in cell PMN of cell to in with or to directed cell the the with to with in PMN cell in PMN to of in with of in with to in in a of as in of as of to the the of leukocyte a of a to with of in with in a to a of of the with of in PMN the of in with a the the of PMN of as in to in to cell with as to with the of a to the of of the to as the in PMN chemotaxis. PMN as the of the in as a of in to in or with or or of a PMN of with a the edge of the the the to the of in the to the PMN the to a to a with a of the a the of the of in the as as a with of of the a of in the of in the of the the of as the of toward the to with in with the cell with in as of the PMN to a to a of a with the the with the with the with the the with a to of the the of a or with to a of with the a in the of cell in the of of the to to to the cell of cell the of the the cell the the of to the as the the cell as the of the of the to the as a as the the cell to the of the cell the of the of to the as the of the as the of the of the the the cell the the cell with of cell the with a to with a cell a of to cell to PMN in cell to the of with to with the of or of the volume, cell cell cell the with to of a as to of in to with the of of the to a of in with to to with the of cell with a of as a of of a with or with the to of the as a in in of the to a PMN of in with or of to to with of to the to the of the of of with as or of with the to with as of of PMN of in phagocytosis of in phagocytosis PMN chemotaxis. the to in of the with PMN in to a in PMN chemotaxis. in the a a of of the of to a in the to a the of with of PMN to in a with to of the PMN to the to a of in a with of in to of in to to to of to in a toward the the in to as to as the of the to the a to a the of directed movement the of the in with the PMN of or movement in the of of in to in with to the of with of as with to the to the PMN the of the of the of of or movement in the of in to the in a of with to a as the of a of of the of in to the of to the of a with of the to cell of to the a of in the PMN in to of with the of in the with of PMN in cell the as a the in wit