Rapid Microscale Synthesis, a New Method for Lead Optimization Using Robotics and Solution Phase Chemistry:  Application to the Synthesis and Optimization of Corticotropin-Releasing Factor₁Receptor Antagonists

Abstract

ADVERTISEMENT RETURN TO ISSUEPREVLetterNEXTRapid Microscale Synthesis, a New Method for Lead Optimization Using Robotics and Solution Phase Chemistry: Application to the Synthesis and Optimization of Corticotropin-Releasing Factor1 Receptor AntagonistsJeffrey P. Whitten, Yun Feng Xie, Philip E. Erickson, Thomas R. Webb, Errol B. De Souza, Dimitri E. Grigoriadis, and James R. McCarthyView Author Information Neurocrine Biosciences, 3050 Science Park Road, San Diego, California 92121 Cite this: J. Med. Chem. 1996, 39, 22, 4354–4357Publication Date (Web):October 25, 1996Publication History Received20 May 1996Published online25 October 1996Published inissue 1 January 1996https://doi.org/10.1021/jm960148mCopyright © 1996 American Chemical SocietyRIGHTS & PERMISSIONSArticle Views442Altmetric-Citations55LEARN ABOUT THESE METRICSArticle Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days.Citations are the number of other articles citing this article, calculated by Crossref and updated daily. Find more information about Crossref citation counts.The Altmetric Attention Score is a quantitative measure of the attention that a research article has received online. Clicking on the donut icon will load a page at altmetric.com with additional details about the score and the social media presence for the given article. Find more information on the Altmetric Attention Score and how the score is calculated. Share Add toView InAdd Full Text with ReferenceAdd Description ExportRISCitationCitation and abstractCitation and referencesMore Options Share onFacebookTwitterWechatLinked InReddit Read OnlinePDF (181 KB) Get e-AlertsSupporting Info (2)»Supporting Information Supporting Information SUBJECTS:Antagonists,Chemical synthesis,Receptors,Solution phase,Triazine Get e-Alerts