High Throughput Screening: The Discovery of Bioactive Substances

Abstract

Natural Products as a Discovery Resource, edited by John P. Devlin Chemical Diversity and Genetic Equity: Synthetic and Naturally Derived Compounds, John P. Devlin Microcollection of Plants for Biochemical Profiling, John P. Devlin Enzymes and Microbes as a Source of Chemical Diversity, Saul L. Neidleman The Marine Environment as a Discovery Resource, Gregg R. Dietzman Compound Sourcing: Chemically Generated Screening Libraries, edited by Michael R. Pavia Introduction, Michael R. Pavia Rapidly Expanding Molecular Diversity: Libraries from Libraries, John S. Kiely, Barbara Dorner, John M. Ostresh, Colette Dooley, and Richard A. Houghten Synthesis of Encoded Small Molecule Combinatorial Libraries via ECLiPS, Jack J. Baldwin and Ian Henderson Parallel Organic Synthesis Using Parke-Davis' Diversomer(R) Method, Sheila Hobbs DeWitt and Anthony W. Czarnik Rapid Discovery and Optimization of Biologically Active Small Molecules Using Automated Synthesis Methods, Adnan M. M. Mjalli and Barry E. Toyonaga CMT: A Solution Phase Combinatorial Chemistry Approach: Synthesis and Yield Prediction Phenazines, Ferenc Darvas and Laszlo Kovacs Design of a Diverse Screening Library, David E. Patterson, Allan M. Ferguson, Richard D. Cramer, Cheryl D. Garr, Ted L. Underiner, and John R. Peterson Automating Combinatorial Chemistry: Challenges and Pitfalls, Jill H. Hardin and Frank R. Smietana Combi-chem High Throughput Screening for Leads Optimization, Richard M. Kris, Patti Willson, Serene Josiah, Marianne Wildgoose, Helen Yeoman, Viktor Krchnak, Stephen Baum, and Stephen Felder Assay Technologies and Detection Methods, edited by Alfred J. Kolb Introduction, Alfred J. Koin Bioassay Design and Implementation, Robert W. Wallace and Mark E. Goldman Scintillation Proximity Assays, Martino Picardo and Kelvin T. Hughes FlashPlate(TM) Technology, Beverly A. Brown, Margaret Cain, Jeff Broadbent, Sharon Tompkins, Georgette Henrich, Rich Joseph, Sally Casto, Harry Harney, Rick Greene, Ron Delmondo, and Simon Ng Assays for Small Molecule Agonists and Antagonists of the Neurotrophin Receptors, Maureen H. Beresini, Michael D. Sadick, Amy L. Galloway, Randy Yen, Sherry H. Yeh, Andy C. Chang, David L. Shelton, and Wai Lee T. Wong A Homogeneous, Time-Resolved Fluorescence Method for Drug Discovery, Alfred J. Kolb, Jocelyn W. Burke, and Gerard Mathis Time-Resolved Fluorometry: Advantages and Potentials, Ilkka Hemmila Adaptation of Time-Resolved Fluorescence to Homogeneous Screening Formats, Janet M. Kolb, Greg Yamanaka, and Susan P. Manly Fluorescence Polarization, J. Richard Sportsman, Sandra K. Lee, Hara Dilley, and Robert Bukar Reporter Gene Assay Applications, Winfried Scheirer Development of a Gene Expression-Based Screen Using Quantitative Polymerase Chain Reaction, D. K. H. Lee, E. T. Wilkinson, S. Cheifetz, and S. A. De Grandis High-Performance Microphysiometry in Drug Discovery, M. Liisa Alajoki, Gregory T. Baxter, William R. Bemiss, David Blau, Luc J. Bousse, Samuel D. H. Chan, Timothy D. Dawes, Karen M. Hahnenberger, James M. Hamilton, Philip Lam, Richard J. McReynolds, Douglas N. Modlin, John C. Owicki, J. Wallace Parce, Dana Redington, Knute Stevenson, H. Garrett Wada, and Jana Williams Bioanalytical Applications of BIAcore, an Optical Biosensor, Francois Legay, Patrick Albientz, and Rudiger Ridder Automation and Robotics, edited by Alfred J. Kolb Introduction, Alfred J. Kolb Management and Service Issues of a Centralized Robotic HTS Core, John Babiak Flexible Use of People and Machines, Mark Beggs and John S. Major Bar-Code Technology and a Centralized Database: Key Components in a Radioligand Binding Program, Elizabeth A. Kunysz, Melissa Lukes, and Douglas W. Bonhaus Factors for the Successful Integration of Assays, Equipment, Robotics, and Software, Dejan Bojanic, Wilma W. Keighley, Mike J. Russell, and Terry P. Wood Accelerating the Discovery Process with Automation and Robotics: A Sure Bet or a Risky Venture?, Richard K. Brown and Andree Proulx Persp