MALDI for fast DNA analysis and sequencing

摘要

Matrix-assisted laser desorption/ionization (MALDI) has been pursued for fast DNA analysis and sequencing. In this article, recent progress on detecting large oligonucleotides is reviewed. The potential application of MALDI for population screening for disease diagnosis is discussed. The approach of using MALDI for DNA sequencing is presented. Discussion on the use of robotic and automation to speed up the mass spectrometer sequencing process is also included. © 1996 John Wiley & Sons, Inc.