Surgical management of thymic tumors: a narrative review with focus on robotic-assisted surgery

摘要

Background and Objective: Thymic epithelial tumors, including thymomas and thymic carcinomas, represent the most common mediastinal tumors and account for up to 50% of all anterior mediastinal tumors. For early stages of these thymic tumors, complete resection of the entire thymus is the recommended treatment. The transition from open surgery to video-assisted thoracoscopic surgery (VATS) and recently to robotic-assisted thoracic surgery (RATS) has fundamentally altered the treatment of thymic tumors. While RATS has been widely implemented due to its many advantages including good visualization with magnification and three-dimensional vision, improved maneuverability and precise instrument control, different techniques have been described. This narrative review focuses on the main approaches and outcomes of RATS thymectomy. It compares the technical, perioperative and clinical outcomes of RATS thymectomy, in particular, with VATS and open thymectomy. Methods: A non-systematic review for full text studies written in the English language was conducted using the PubMed search engine and literature was summarized. Key Content and Findings: We present an overview of robotic-assisted resection for thymomas and review the main approaches and outcomes of RATS thymectomy. Critical points of the RATS approach, including surgical specifics and pitfalls, are presented. Technical advantages and disadvantages of each technique are discussed. The perioperative and clinical outcomes of RATS thymectomy are compared, where possible, to those for VATS and open thymectomy. Currently, retrospective analyses demonstrate comparable or even more favorable outcomes following a RATS approach in comparison to VATS and open approaches in terms of operating time, conversion rates, intraoperative complications, completeness of resection and mortality. Certain analyses also report better outcomes for patients undergoing RATS thymectomy in terms of blood loss, postoperative complications, duration of pleural drainage and length of hospital stay compared to VATS and open thymectomy. Conclusions: Overall, RATS has shown promising results and could become the preferred technique for resection of thymic tumors. It shows good outcomes compared to VATS and open thymectomy in the current literature. However, especially for extended tumors with the need for extended resection and reconstruction, open thymectomy remains a valuable approach.