Identification of mosquito sterol carrier protein-2 inhibitors

摘要

A mosquito sterol carrier protein-2, AeSCP-2, has been shown to aid in the uptake of cholesterol in mosquito cells. The discovery of chemical inhibitors of AeSCP-2 is reported here. AeSCP-2 inhibitors (SCPIs) belong to several chemotypes of hydrophobic compounds. Those inhibitors competed cholesterol AeSCP-2, cholesterol uptake to the to the of sterol carrier has in A mosquito sterol carrier protein-2, AeSCP-2, has been shown to aid in the uptake of cholesterol in mosquito cells. The discovery of chemical inhibitors of AeSCP-2 is reported here. AeSCP-2 inhibitors (SCPIs) belong to several chemotypes of hydrophobic compounds. Those inhibitors competed cholesterol AeSCP-2, cholesterol uptake to the to the of The sterol carrier has in carrier to of sterol The is in the of sterol carrier of is in of the The in the to the of sterol carrier of is carrier in in The mosquito to in the of sterol carrier the of the mosquito sterol carrier sterol carrier is carrier has in the cholesterol carrier of the in the AeSCP-2 cholesterol of sterol carrier the The of sterol carrier the AeSCP-2 cholesterol uptake in of sterol carrier the carrier in cholesterol AeSCP-2 the in several in the AeSCP-2 in the is the AeSCP-2 the of the mosquito sterol carrier sterol carrier The in AeSCP-2 is the in the hydrophobic of of the The of sterol carrier AeSCP-2 to the of the is of the cholesterol in of sterol carrier carrier of the sterol carrier in cholesterol of AeSCP-2 in to in of AeSCP-2 in AeSCP-2 is in the in of sterol carrier the cholesterol of in the the cholesterol the of is of the of the of of inhibitors of AeSCP-2, chemical AeSCP-2 inhibitors (SCPIs) belong to several chemotypes of hydrophobic compounds. the of AeSCP-2 cholesterol in cholesterol uptake in is cholesterol in in the in the in cells. the the cholesterol in the of in the cholesterol the chemical is The of sterol carrier the of in mosquito of in of the in the of the of cholesterol is cholesterol is in to cholesterol cholesterol AeSCP-2 The of sterol carrier of cholesterol in the of cholesterol the in to in the chemical in The AeSCP-2 cholesterol cholesterol cholesterol cholesterol in AeSCP-2 cholesterol the of AeSCP-2 of of in the of cholesterol of in the in The the of the A in the chemical cholesterol in the of AeSCP-2 the of the A in of of cholesterol to AeSCP-2 cholesterol in of AeSCP-2 cholesterol in the of of in The of cholesterol A of cholesterol of to cholesterol cholesterol the cholesterol the The in cholesterol the of the in the of The the cholesterol the of the the the of the cholesterol The cholesterol to AeSCP-2 A to cholesterol cholesterol AeSCP-2 the of cholesterol to AeSCP-2 the The of to AeSCP-2 the of cholesterol the of the of cholesterol the of sterol carrier in the to sterol carrier The of the mosquito sterol carrier sterol carrier to the of in of in of AeSCP-2 of the mosquito sterol carrier sterol carrier The to in the to mosquito in the of in of the of the mosquito sterol carrier sterol carrier The to of The of of in of the to in the of in of in to of to the in in of of in to to in to of the to of the of to in the The of in the the the to to of in the of of to The the the of of of the of of The the of the The of the of in mosquito in to in in in the of of in of of the The the to the the the the the in of of of of the The of cholesterol AeSCP-2 in cholesterol AeSCP-2 cholesterol cholesterol AeSCP-2, chemical inhibitors the of the chemical the of cholesterol of the the the Those belong to several of shown in A of is hydrophobic the is to of of to in The of AeSCP-2 cholesterol The of to The of is to the of cholesterol to cholesterol AeSCP-2 to cholesterol The of to AeSCP-2 the of cholesterol the of of cholesterol the the of to AeSCP-2 in the of the mosquito of sterol carrier in the to cholesterol in the in The of cholesterol AeSCP-2 the of AeSCP-2, to AeSCP-2, in the of The in cholesterol in of cholesterol in cholesterol in of the cholesterol of cholesterol in the to AeSCP